ARL11 Polyclonal Antibody, 100ul Serum Kelch-like ECH-associated protein 1 interacts

Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus

Many alternatively spliced transcript variants exist for this gene

or a potent one when fused with a heterologous protein containing a KRAB B-domain

Another variant encoding an N-terminally truncated isoform has been reported

Alternative splicing and the use of alternative promoters results in multiple transcript variants

ARL11 Polyclonal Antibody, 100ul Serum Kelch-like ECH-associated protein 1 interactsThis gene encodes a tumor suppressor related to the ADP ribosylation factor (ARF) family of proteins. The encoded protein may play a role in apoptosis in a caspase dependent manner. Polymorphisms in this gene have been associated with some familial cancers.