Nutlin-3, (4R5S, and 4S5R) Catalog No.:M7686-10 In vitro cytotoxicity and in

In vitro cytotoxicity and in vivo efficacy

CHR-2797 exhibits profound anti-proliferative effects against a range of cancer cell lines such as U-937

Formula: C25H24N4O2

27)28)29-24(32)20-4-2-19(3-5-20)17-30-12-14-33-15-13-30/h2-7

3)28)22-18(26)11-15(12-19(22)27)8-9-21(31)32/h4-9

Nutlin-3, (4R5S, and 4S5R) Catalog No.:M7686-10 In vitro cytotoxicity and inNutlin 3 is an inhibitor of MDM2 (human homolog of murine double minute 2), which disrupts its interaction with p53, leading to the stabilization and activation of p53. Nutlin 3 activates the p53 pathway and efficiently induces apoptosis in tumours with amplified MDM2 gene and overexpression of MDM2 protein. Product information CAS Number: 548472 68 0 Molecular Weight: 581. 49 Formula: C30H30Cl2N4O4 Synonym: () Nutlin 3 Nutlin 3 Related CAS Number: