JNJ-42041935 - HIF-PHD Inhibitor. CAS# 1193383-09-3 size:10mg solid 88)/p+1/t21-

88)/p+1/t21-

InChi: InChI=1S/C16H15NO7S/c1-10-2-5-12(6-3-10)25(22

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

and the PI3K/Akt or PTEN mutational status

OSI-027 shows robust antitumor activity in several different human xenograft models representing various histologies

JNJ-42041935 - HIF-PHD Inhibitor. CAS# 1193383-09-3 size:10mg solid 88)/p+1/t21-JNJ 42041935, CAS No. 1193383 09 3, is a potent and selective HIF PHD inhibitor. It is a 2 OG competitive and reversible inhibitor for PHD enzymes (pKis = 7. 91, 7. 29, and 7. 65 for PHD1, 2, and 3, respectively). It is >100 fold selective for PHD compared to the related FIH (factor inhibiting HIF) and a panel of various other enzymes. In an inflammation induced anemia model in rats, 100 M kg day JNJ 42041935 significantly increased the number of