OSI-930 fenadine HCl Gaudiano EF

Gaudiano EF

Formula: C15H11NS

blocks Wnt-induced LRP6 phosphorylation

Rociletinib

SB203580 also inhibits the activity of PDK1 in a dose-dependent manner with an IC50 in the 3–10 μm range

OSI-930 fenadine HCl Gaudiano EFOSI 930 is a selective thiophene derived tyrosine kinase inhibitor with potential antineoplastic activity. Tyrosine kinase inhibitor OSI 930 inhibits stem cell factor receptor (c Kit) and the vascular endothelial growth factor receptor 2 (VEGFR2), which may result in the inhibition of both tumor cell proliferation and tumor angiogenesis. Both c Kit and VEGFR2 are overexpressed in a variety of cancers. Check for active clinical trials or closed