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Y-39983 HCl - CAS# 173897-44-4 0217 CAS Number: 890842-28-1

Y-39983 HCl - CAS# 173897-44-4 0217 CAS Number: 890842-28-1

Name: Y-39983 HCl - CAS# 173897-44-4 0217 CAS Number: 890842-28-1
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Y-39983 HCl - CAS# 173897-44-4 0217 CAS Number: 890842-28-1Y 39983 HCl, CAS No. 173897 44 4, also known as Y 33075, is a potent and selective inhibitor of ROCK family with IC50 value of 3. 6nM for ROCK. Y 39983 attenuates experimental autoimmune encephalomyelitis via inhibition of demyelination. Y 39983 downregulates RhoA Rho associated kinase expression during its promotion of axonal regeneration. Y 39983, promotes regeneration of crushed axons of retinal ganglion cells into the optic nerve of adult cats.

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Description

CAS Number: 890842-28-1

PubMed PMID: 24690597

PARP inhibitor with selectivity toward ADP-ribosyltransferase ARTD3/PARP3

It also binds to D4 (pKi = 7

936890-98-1

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