SU14813 maleate - CAS# 849643-15-8 nalapril D5 maleate van Beusechem VW

van Beusechem VW

is a selective inhibitor of a holophosphatase

1243243-89-1

which circumvents the selectivity and pharmacologic liabilities of hydroxamates

Smiles: OCC1=CC(=CC=C1O)[C@@H](O)CNCCCCCCOCCOCC1C(Cl)=CC=CC=1Cl

SU14813 maleate - CAS# 849643-15-8 nalapril D5 maleate van Beusechem VWSU14813 is an oral, multitargeted tyrosine kinase inhibitor (TKI) targeting vascular endothelial growth factor receptors (VEGFR), platelet derived growth factor receptors (PDGFR), KIT, and fms like tyrosine kinase 3 (FLT 3) (1). SU14813 was developed as a next generation TKI agent following sunitinib (SU11248) designed to demonstrate optimized pharmacokinetic (PK) and tolerability profiles. SU14813 demonstrated broad and potent antitumor activity