ENMD-2076 60090 Smiles: COC1C2C=COC=2C(OC[C@@H](O)C(C)(C)O)=C2OC(=O)C=CC2=1

Smiles: COC1C2C=COC=2C(OC[C@@H](O)C(C)(C)O)=C2OC(=O)C=CC2=1

Water: 26 mg/mL(59

Meeting: 2011 ASCO Annual Meeting

pharmacokinetics and clinical activity of VS-6063

InChi: InChI=1S/C25H28ClN5O5S2/c1-13-18(23-19-7-16(26)3-2-14(19)4-5-29-23)9-22(37-13)24(33)20-10-28-12-30-25(20)31-17-6-15(21(32)8-17)11-36-38(27

ENMD-2076 60090 Smiles: COC1C2C=COC=2C(OC[C@@H](O)C(C)(C)O)=C2OC(=O)C=CC2=1ENMD 2076 is an orally active, Aurora A angiogenic kinase inhibitor with a unique kinase selectivity profile and multiple mechanisms of action. ENMD 2076 has been shown to inhibit a distinct profile of angiogenic tyrosine kinase targets in addition to the Aurora A kinase. Aurora kinases are key regulators of mitosis (cell division), and are often over expressed in human cancers. ENMD 2076 also targets the VEGFR, Flt 3 and FGFR3 kinases which have been