RI-1 - CAS# 415713-60-9 ihydrochloride InChiKey: OUEODVPKPRQETQ-CHWSQXEVSA-N

InChiKey: OUEODVPKPRQETQ-CHWSQXEVSA-N

C6H6O3S/c1-22(2)20(30)28-19-13(34-22)6-7-16(27-19)26-18-12(23)10-24-21(29-18)25-11-8-14(31-3)17(33-5)15(9-11)32-4

CAS Number: 2070009-25-3

it inhibits the tyrosine kinase receptor TIE2 and FMS-related tyrosine kinase receptor-3 (Flt3)

also known as S-4661 and Finibax

RI-1 - CAS# 415713-60-9 ihydrochloride InChiKey: OUEODVPKPRQETQ-CHWSQXEVSA-NRI 1 is an irreversible inhibitor of RAD51 (IC50s = 5 30 M), a protein that is central to homologous recombination during DNA repair and is overexpressed in a wide range of human cancer cell types. RI 1 specifically reduces gene conversion in human cells while stimulating single strand annealing. RI 1 binds covalently to the surface of RAD51 protein at cysteine 319 that likely destabilizes an interface used by RAD51 monomers to oligomerize into