LDN-193189 - BMP inhibitor. CAS# 1062368-24-4 Catalog No.:M60008-10S It inhibits phosphorylation of the

It inhibits phosphorylation of the mTORC1 substrates 4E-BP1 and S6K1 as well as the mTORC2 substrate AKT in diverse cancer models in vitro and in vivo

Histone demethylation mediated by the nuclear amine oxidase homolog LSD1

Formula: C31H31NO3

It exhibits potent inhibitory activity of Notch signaling in tumor cells

(2012) PCT WO 2012009678

LDN-193189 - BMP inhibitor. CAS# 1062368-24-4 Catalog No.:M60008-10S It inhibits phosphorylation of theLDN 193189, CAS No. 1062368 24 4, is a cell permeable, highly potent and selective BMP pathway inhibitor by inhibiting BMP type I receptors ALK2 (IC50=5 nM) and ALK3 (IC50=30 nM), but not ALK4, ALK5, and ALK7 (> 0. 5 M). It prevents Smad1, Smad5, and Smad8 phosphorylation. It is a useful tool compound to modulate stem cell differentiation (for example, neural differentiation of human ESC iPSC in combination with SB431542). It was also used in animal