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Periactin 4mg Tablets 20'S MDF Formulated for dry and damagedCyproheptadine is an antihistamine used to relieve allergy symptoms such as watery eyes, runny nose, itching eyes nose, sneezing, hives, and itching. It works by blocking a certain natural substance (histamine) that your body makes during an allergic reaction. This medication also blocks another natural substance in your body (serotonin).