VX-222 cis - CAS# 1026785-59-0 Catalog No.:M10875-2 serving many of the same
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VX-222 cis - CAS# 1026785-59-0 Catalog No.:M10875-2 serving many of the sameLomibuvir, also known as VX 222, VCH 222 and VX22, is an nonnucleoside NS5B polymerase inhibitor. VX 222 inhibits the 1b Con1 HCV subgenomic replicon, with 50% effective concentrations (EC(50)s) 5 nM. VX 222 binds to the HCV polymerase with dissociation constants of 17 nM. In phase 1 and 2 clinical studies, VX 222 demonstrated effective antiviral efficacy, with substantial reductions in plasma HCV RNA in patients chronically infected with genotype 1
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