I-BET762 (GSK525762) - BET Inhibitor. CAS# 1260907-17-2 60186 InChiKey: WWONFUQGBVOKOF-UHFFFAOYSA-N

InChiKey: WWONFUQGBVOKOF-UHFFFAOYSA-N

7 µM concentration in beta cell proliferation assays

Smiles: O=C(C1C=CC(F)=CC=1)N1C[C@H](CCC1)C1=NC(=NO1)C1C=CC(F)=CC=1

Radio-sensitization of human leukaemic MOLT-4 cells by DNA-dependent protein kinase inhibitor

HCQ was an effective growth inhibitor of human RCC cell lines

I-BET762 (GSK525762) - BET Inhibitor. CAS# 1260907-17-2 60186 InChiKey: WWONFUQGBVOKOF-UHFFFAOYSA-NI BET762 (GSK525762), CAS No. 1260907 17 2, is a novel, highly potent, selective and cell permeable inhibitor of the bromodomain and extra terminal (BET) family protein BRD4 with an IC50 of ~35 nM. It suppresses the production of proinflammatory proteins by macrophages and blocks acute inflammation. It is highly selective over other bromodomain containing proteins. In vivo studies using I BET762 have demonstrated efficacy in a range of oncology and