CDKI-73 60295 PubMed PMID: 25059319

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CDKI-73 60295 PubMed PMID: 25059319CDKI 73 is a potent CDK9 inhibitor with Ki of 4 nM. It shows selective toxicity to CLL cells(LD50=80 nM) versus normal B cell and normal CD34+ cell(LD50>20 uM). The inhibition of CDK9 induces apoptosis and potentiates the effect of cisplatin. Product information CAS Number: 1421693 22 2 Molecular Weight: 394. 45 Formula: C15H15FN6O2S2 Chemical Name: 3 ({5 fluoro 4 [4 methyl 2 (methylamino) 1,3 thiazol 5 yl]pyrimidin 2 yl}amino)benzene 1 sulfonamide

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