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RG7112 - CAS# 939981-39-2 Catalog No.:M10990-10 which is a triazole antifungal

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RG7112 - CAS# 939981-39-2 Catalog No.:M10990-10 which is a triazole antifungalRO5045337, also known as RG7112, is a MDM2 antagonist with potential antineoplastic activity. RO5045337 binds to MDM2, thereby preventing the binding of the MDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53. By preventing this MDM2 p53 interaction, the proteosome mediated enzymatic degradation of p53 is inhibited and the transcriptional activity of p53 is restored, which may result in the restoration of p53

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Description

which is a triazole antifungal agent

Akt inhibitor GSK2141795 binds to and inhibits the activity of Akt

2013 Feb 15

2R)-cyclohexane-1

Obatoclax binds to members of the Bcl-2 protein family

RG7112 - CAS# 939981-39-2 Catalog No.:M10990-10 which is a triazole antifungalRO5045337, also known as RG7112, is a MDM2 antagonist with potential antineoplastic activity. RO5045337 binds to MDM2, thereby preventing the binding of the MDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53. By preventing this MDM2 p53 interaction, the proteosome mediated enzymatic degradation of p53 is inhibited and the transcriptional activity of p53 is restored, which may result in the restoration of p53

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