XMD8-92 Size:Solid 2 mg clemizole exhibits a sixfold selectivity

clemizole exhibits a sixfold selectivity for TRPC5 over TRPC4β (IC50 = 6

8 and 16 μM) significantly inhibits the proliferation of A2780 and SK-OV-3 cell lines in a dose- and time-dependent manner

11 cells which express native (unmutated) FLT3

Formula: C23H25ClN4O2S

Following treatment with E7070

XMD8-92 Size:Solid 2 mg clemizole exhibits a sixfold selectivityXMD8 92 is an ERK5 BMK1 inhibitor and also BRD4 inhibitor. XMD8 92 inhibits pancreatic tumor xenograft growth via a DCLK1 dependent mechanism. XMD8 92 blocks cellular BMK1 activation and significantly suppresses tumor growth in lung and cervical tumor models and is well tolerated in animals. Product information CAS Number: 1234480 50 2 Molecular Weight: 474. 55 Formula: C26H30N6O3 Chemical Name: 5 {[2 ethoxy 4 (4 hydroxypiperidin 1 yl)phenyl]amino}