INCB 3284 dimesylate - CAS# 887401-93-6 toprolol tartrate Ropivacaine Hydrochloride Monohydrate causes reversible
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INCB 3284 dimesylate - CAS# 887401-93-6 toprolol tartrate Ropivacaine Hydrochloride Monohydrate causes reversibleINCB3284 is a potent, selective, and orally bioavailable hCCR2 Antagonist. INCB3284 exhibited an IC50 of 3. 7 nM in antagonism of monocyte chemoattractant protein 1 binding to hCCR2, an IC50 of 4. 7 nM in antagonism of chemotaxis activity, an IC50 of 84 M in inhibition of the hERG potassium current, a free fraction of 58% in protein binding, high selectivity over other chemokine receptors and G protein coupled receptors, and acceptable oral
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