INCB3344 - CAS# 1262238-11-8 Size:Solid 2 mg is a selective inhibitor of

is a selective inhibitor of transforming growth factor-β type I receptor (ALK5

Trimetrexate is a quinazoline derivative

Smiles: CN1C2=CC(=CC=C2N=C1COC1C=CC(CC2SC(=O)NC2=O)=CC=1)OC1C=C(C)C(N)=C(C)C=1

InChi: InChI=1S/C12H11N3O/c16-12-9-7-11(8-1-4-13-5-2-8)15-10(9)3-6-14-12/h1-2

Schneider R

INCB3344 - CAS# 1262238-11-8 Size:Solid 2 mg is a selective inhibitor ofINCB3344 is a potent and selective antagonist of CCR2 receptor with IC(50) values of 5. 1 nM (hCCR2) and 9. 5 nM (mCCR2) in binding antagonism and 3. 8 nM (hCCR2) and 7. 8 nM (mCCR2) in antagonism of chemotaxis activity. INCB3344 exhibited >100 fold selectivity over other homologous chemokine receptors, a free fraction of 24% in human serum and 15% in mouse serum, and an oral bioavailability of 47% in mice, suitable as a tool compound for target