SHP099 xHCl - SHP2 Phosphatase Inhibitor. CAS# 1801747-11-4 60305 and is brain penetrant

and is brain penetrant

1801787-56-3

and is competitive with S-adenosylmethionine (SAM) and non-competitive with peptide substrates

SAG induces Hedgehog pathway activation with an EC50 of ~3 nM in NIH 3T3-derived Shh-LIGHT2 cells and counteracts Cyclopamine-KAAD inhibition of Smo

Formula: C21H24N4O3

SHP099 xHCl - SHP2 Phosphatase Inhibitor. CAS# 1801747-11-4 60305 and is brain penetrantSHP099, CAS No. 1801747 11 4, is a potent, selective, orally bioavailable, and efficacious SHP2 inhibitor with IC50 =0. 07 M and p ERK modulation in cells IC50 = 0. 250 M. SHP099 exhibits dose dependent pathway inhibition and antitumor activity in xenograft models. SHP2 is a nonreceptor protein tyrosine phosphatase (PTP) encoded by the PTPN11 gene involved in cell growth and differentiation via the MAPK signaling pathway. SHP2 also purportedly plays