MDV-3100 - CAS# 915087-33-1 60135 Class III receptor tyrosine kinase

Class III receptor tyrosine kinase inhibitor AC220 selectively inhibits class III receptor tyrosine kinases

unfolded protein accumulation leads to activation of the endoplasmic reticulum transmembrane kinase/endoRNase (RNase) IRE1α

) significantly delays in lymphoma development and shows 100- to 1

is an allosteric inhibitor of Bcr-abl tyrosine kinase activity (IC50 = 267 nM)

Molecular Weight: 1415

MDV-3100 - CAS# 915087-33-1 60135 Class III receptor tyrosine kinaseEnzalutamide, also known as MDV3100, CAS No. 915087 33 1, is an orally bioavailable, organic, non steroidal small molecule targeting the androgen receptor (AR) with potential antineoplastic activity. Through a mechanism that is reported to be different from other approved AR antagonists, selective androgen receptor modulator MDV3100 inhibits the activity of prostate cancer cell ARs, which may result in a reduction in prostate cancer cell proliferation