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Metarrestin (ML246) Size:100 mg solid Smiles: CN1C(=O)N(C2=C1C=NC1=CC=C(C=C12)C1=CN=C(C=C1)OC)C1=CC=C(C=C1)N1CCNC(C1)C(F)(F)F

Metarrestin (ML246) Size:100 mg solid Smiles: CN1C(=O)N(C2=C1C=NC1=CC=C(C=C12)C1=CN=C(C=C1)OC)C1=CC=C(C=C1)N1CCNC(C1)C(F)(F)F

Name: Metarrestin (ML246) Size:100 mg solid Smiles: CN1C(=O)N(C2=C1C=NC1=CC=C(C=C12)C1=CN=C(C=C1)OC)C1=CC=C(C=C1)N1CCNC(C1)C(F)(F)F
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SKU: 25725816994
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SKU: 25725816994

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Metarrestin (ML246) Size:100 mg solid Smiles: CN1C(=O)N(C2=C1C=NC1=CC=C(C=C12)C1=CN=C(C=C1)OC)C1=CC=C(C=C1)N1CCNC(C1)C(F)(F)FMetarrestin (ML246) is an orally active and specific perinucleolar compartment (PNC) inhibitor that disrupts the nucleolar structure and inhibits RNA polymerase (Pol) I transcription. Metarrestin blocks metastatic development and extends survival in mouse cancer models. Product information CAS Number: 1443414 10 5 Molecular Weight: 474. 60 Formula: C31H30N4O Chemical Name: Trans 4 (7 benzyl 4 imino 5,6 diphenyl 4,7 dihydro 3H pyrrolo[2,3 d]pyrimidin 3

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Description

Smiles: CN1C(=O)N(C2=C1C=NC1=CC=C(C=C12)C1=CN=C(C=C1)OC)C1=CC=C(C=C1)N1CCNC(C1)C(F)(F)F

IRE-3 can also block enzymatic activities of IRE1α in INS-1 rat insulinoma cell lines

4 nM (PKC-βI)

PMID: 30099457

2817-2822 (2004)

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