PFI-2 Hydrochloride FKBP Degrader-3 Chemical Name: (4R)-N-[14-[(6S)-4-(4-chlorophenyl)-2

Chemical Name: (4R)-N-[14-[(6S)-4-(4-chlorophenyl)-2

U87 and Seg1 cells

(-)-Isosteviol

It reduces antigen-induced histamine release from rat conjunctival tissue by 46% in vitro when used at a concentration of 10 µg/ml

6-tetrahydropyridine-3-carbonyl)glycine

PFI-2 Hydrochloride FKBP Degrader-3 Chemical Name: (4R)-N-[14-[(6S)-4-(4-chlorophenyl)-2PFI 2 is a potent inhibitor of SETD7 with IC50 2 nM and 1000 fold selectivity over other methyltransferases and other non epigenetic targets. PFI 2 has been shown to bind to SETD7 by ITC (Kd=18nM) and biotinylated PFI 2 interacts with SETD7 in pull down studies. Its enantiomer (S) PFI 2 is 500 fold less active making it an excellent negative control. Treatment of low density MEFs with (R) PFI 2 resulted in higher nuclear YAP levels indicating an