AZD-5438 Size:Solid 2 mg selective and bioavailable CK2 (Casein

selective and bioavailable CK2 (Casein Kinase 2) Inhibitor with IC50 of 1 nM

ZINC4758640

a novel and potent p21-activated kinase 4 inhibitor

which is an angiotensin converting enzyme (ACE) inhibitor

Losartan D4 Carboxylic Acid (E-3174 D4) is the deuterium labeled Losartan(EXP-3174)

AZD-5438 Size:Solid 2 mg selective and bioavailable CK2 (CaseinAZD5438 is a potent inhibitor of cyclin dependent kinase (cdk) 1, 2, and 9 (IC(50), 16, 6, and 20 nmol L, respectively). In vitro, AZD5438 showed significant antiproliferative activity in human tumor cell lines (IC(50) range, 0. 2 1. 7 micromol L), causing inhibition of the phosphorylation of cdk substrates pRb, nucleolin, protein phosphatase 1a, and RNA polymerase II COOH terminal domain and blocking cell cycling at G(2) M, S, and G(1) phases.