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Pentoxifylline CS JNK 5a ZLN005 is a useful chemical

SKU: 11919962663

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Pentoxifylline CS JNK 5a ZLN005 is a useful chemicalPentoxifylline is a drug used to treat muscle pain in people with peripheral artery disease. Like other methylated xanthine derivatives, pentoxifylline is a competitive nonselective phosphodiesterase inhibitor which raises intracellular cAMP, activates PKA, inhibits TNF and leukotriene synthesis, and reduces inflammation and innate immunity. It is being investigated for treatment of Alzheimer's disease. It is generic and sold under many brand names

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Description

ZLN005 is a useful chemical probe to study this target

6-di(H)methyl-1

PubMed PMID: 24676877

1038/srep19640

HCT-116 and MiaPaca cells

Pentoxifylline CS JNK 5a ZLN005 is a useful chemicalPentoxifylline is a drug used to treat muscle pain in people with peripheral artery disease. Like other methylated xanthine derivatives, pentoxifylline is a competitive nonselective phosphodiesterase inhibitor which raises intracellular cAMP, activates PKA, inhibits TNF and leukotriene synthesis, and reduces inflammation and innate immunity. It is being investigated for treatment of Alzheimer's disease. It is generic and sold under many brand names

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