GK921 Catalog No.:M8587-2 AB928 shows rescue of these

AB928 shows rescue of these gene expression changes

PubMed PMID: 25726556

InChi: InChI=1S/C32H46N4O6S/c1-21-28(43-20-34-21)23-15-13-22(14-16-23)18-33-30(41)25-17-24(37)19-36(25)31(42)29(32(2

cells remain viable 1 week post-treatment even at 10 μM of Nutlin-3

Molecular Weight: 460

GK921 Catalog No.:M8587-2 AB928 shows rescue of theseGK921 is a transglutaminase 2 (TGase 2) inhibitor. GK921 showed cytotoxicity to RCC (average GI50 in eight RCC cell lines: 0. 905 M). A single treatment with GK921 almost completely reduced tumor growth by stabilizing p53 in the ACHN and CAKI 1 preclinical xenograft tumor models. TGase 2 inhibitor GK921 abrogates RCC growth in xenograft tumor models, suggesting the possibility of a new therapeutic approach to RCC. Product information CAS Number: