PI 3-kinase p85 Alpha/Gamma Polyclonal Antibody, 50ul Thermo Mix Mutations in this gene are

Mutations in this gene are associated with acute myeloid leukemia

Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats| and an intracellular domain consisting of multiple different domain types

This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype

The gene product also affects fibroblast growth factor signaling

Among its related pathways are Signaling by GPCR and cAMP signaling pathway

PI 3-kinase p85 Alpha/Gamma Polyclonal Antibody, 50ul Thermo Mix Mutations in this gene arePhosphatidylinositol 3 kinase phosphorylates the inositol ring of phosphatidylinositol at the 3 prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. PIK3R1 encodes the 85 kD regulatory subunit. Phosphatidylinositol 3 kinase plays an important role in the metabolic actions of insulin, and a mutation in PIK3R1 has been associated with insulin resistance. Alternative splicing of PIK3R1