Rb Polyclonal Antibody, 50ul[BT-AP07689] Roller Bottles The ligand of this receptor

The ligand of this receptor is macrophage inflammatory protein 3 alpha(MIP-3 alpha)

The encoded protein is a specialized DNA polymerase that catalyzes translesion DNA synthesis| which allows DNA replication in the presence of DNA lesions

The expression patterns provide evidence consistent with a role in fetal skin development and a possible role in cellular proliferation

Defects in this gene are a cause of susceptibility to familial hypertrigliceridemia

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Rb Polyclonal Antibody, 50ul[BT-AP07689] Roller Bottles The ligand of this receptorRB transcriptional corepressor 1 encoded by RB1 is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.