Chk1(Phospho Ser286) Polyclonal Antibody, 20ul sgRNA Library Construction In some types of Ewing

In some types of Ewing tumors

The protein lacks critical active site residues and thus is suggested to be proteolytically inactive

Alternatively spliced transcript variants encoding different isoforms have been described for PDE4C

The alpha subunit includes the skeletal muscle and hepatic isoforms

one of the most conserved proteins known

Chk1(Phospho Ser286) Polyclonal Antibody, 20ul sgRNA Library Construction In some types of EwingThe protein encoded by this gene belongs to the Ser Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells