Survivin Polyclonal Antibody, 20ul[BT-AP14596] Diagnostic Probes & Oligos Isoform 1 but not isoform

Isoform 1 but not isoform 2 is activated through autoproteolytic processing

Microdeletions in this gene are associated with contiguous ABCD1/DXS1375E deletion syndrome (CADDS)

and a conserved C-terminus

TOP2A encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance

An additional gene

Survivin Polyclonal Antibody, 20ul[BT-AP14596] Diagnostic Probes & Oligos Isoform 1 but not isoformThis gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues.