ErbB-3 Polyclonal Antibody, 100ul[BT-AP03043] Lysosome This protein is cytoplasmic but

This protein is cytoplasmic but is often anchored to a peroxisomal membrane where it forms a heteromeric complex and plays a role in the import of proteins into peroxisomes and peroxisome biogenesis

The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distin

subunit:Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc

Expression of this gene may be downregulated in pancreatic cancer

suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells

ErbB-3 Polyclonal Antibody, 100ul[BT-AP03043] Lysosome This protein is cytoplasmic butERBB3 encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation