Phospho-Akt2 (S474) Polyclonal Antibody, 50ul Antibodies May participate in cargo loading

May participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier

In experiments with non-human species

Polymorphism within this gene is associated with variable ability to metabolize mephenytoin

An important paralog of this gene is GPR162

5-triphosphate (PIP3)

Phospho-Akt2 (S474) Polyclonal Antibody, 50ul Antibodies May participate in cargo loadingAKT2 is a putative oncogene encoding a protein belonging to a subfamily of serine threonine kinases containing SH2 like (Src homology 2 like) domains. AKT2 was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. AKT serine threonine kinase 2 is a general protein kinase capable of