RFC1 Polyclonal Antibody, 50ul[BT-AP07768] Vacuum Aspirator Defects in this gene are

Defects in this gene are the cause of hypomagnesemia type 4

The encoded protein homodimerizes and forms the light chain component of the cytoplasmic dynein motor protein complex

It binds to the TGACCT repeat motif enhancing the renin gene and thus acting as a negative modulator of renin gene transcription

The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure

This gene encodes a protein that is one of the two components of elastic fibers

RFC1 Polyclonal Antibody, 50ul[BT-AP07768] Vacuum Aspirator Defects in this gene areRFC1 encodes the large subunit of replication factor C, a five subunit DNA polymerase accessory protein, which is a DNA dependent ATPase required for eukaryotic DNA replication and repair. The large subunit acts as an activator of DNA polymerases, binds to the 3' end of primers, and promotes coordinated synthesis of both strands. It may also have a role in telomere stability. Alternatively spliced transcript variants encoding different isoforms have