Fyb Monoclonal Antibody, 100ul 3D Cell Culture Consumables The protein encoded by POLR1C

The protein encoded by POLR1C (RNA polymerase I subunit C) is a subunit of both RNA polymerase I and RNA polymerase III complexes

an N-terminal DNA-binding domain| a centrally located transcriptional activation domain and a C-terminal domain involved in transcriptional repression

This gene encodes a protein which associates with toll-like receptor 4 on the cell surface and confers responsiveness to lipopolysaccyaride (LPS)

while the protein coding ORF is expressed at high levels in response to stress

respiratory tract

Fyb Monoclonal Antibody, 100ul 3D Cell Culture Consumables The protein encoded by POLR1CThe protein encoded by this gene is an adapter for the FYN protein and LCP2 signaling cascades in T cells. The encoded protein is involved in platelet activation and controls the expression of interleukin 2. Three transcript variants encoding different isoforms have been found for this gene.