Plk1(Phospho Ser137) Polyclonal Antibody, 20ul Nucleic Acid Amplification The heat shock transcription factor

The heat shock transcription factor 2 encoded by HSF2 belongs to the HSF family of transcription factors that bind specifically to the heat-shock promoter element and activate transcription

was once thought to exist

and mutations in this gene have been associated with congenital chloride diarrhea

A mutation in this gene results in inclusion body myopathy-3

and a carboxy-terminal regulatory domain that mediates homodimerization

Plk1(Phospho Ser137) Polyclonal Antibody, 20ul Nucleic Acid Amplification The heat shock transcription factorThe Ser Thr protein kinase encoded by this gene belongs to the CDC5 Polo subfamily. It is highly expressed during mitosis and elevated levels are found in many different types of cancer. Depletion of this protein in cancer cells dramatically inhibited cell proliferation and induced apoptosis; hence, it is a target for cancer therapy.