Trk B Polyclonal Antibody, 50ul[BT-AP09215] Antibody Development This gene was identified in

This gene was identified in the neuroblastoma tumor suppressor candidate region on chromosome 1p36

Studies in mice also suggested that this gene may mediate adrenocorticotropic hormone response to bacterial endotoxin

GTP-binding proteins are GTPases and function as molecular switches that can flip between two states: active

Mutations in this gene have been associated with autosomal dominant spastic paraplegia 6

This protein is a target for SMAD-specific E3 ubiquitin ligases| such as SMURF1 and SMURF2| and undergoes ubiquitination and proteasome-med

Trk B Polyclonal Antibody, 50ul[BT-AP09215] Antibody Development This gene was identified inNTRK2 encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants.