FAK(Phospho Tyr925) Polyclonal Antibody, 20ul Isothermal Amplification Aberrant binding to this subunit

Aberrant binding to this subunit by proteins with expanded polyglutamine regions has been suggested as one of the pathogenetic mechanisms underlying a group of neurodegenerative disorders referred to as polyglutamine diseases

The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme

E2F transcription factors

The protein encoded by this gene is cell-cycle regulated| and has nuclear localization

Rab proteins are prenylated

FAK(Phospho Tyr925) Polyclonal Antibody, 20ul Isothermal Amplification Aberrant binding to this subunitThis gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal