Human Serine/Arginine-rich Splicing Factor 1, SFRS1 ELISA Kit , 96T In vitro Transcription Alternatively spliced transcript variants encoding

Alternatively spliced transcript variants encoding different isoforms have been found for HRH2

The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease| the regulation of the cellular response to hypoxia and induction of apoptosis

A related intronless pseudogene has been mapped to chromosome 5

and function of granulocytes

A related protein interacts with calcium/calmodulin-dependent serine protein kinase (CASK)

Human Serine/Arginine-rich Splicing Factor 1, SFRS1 ELISA Kit , 96T In vitro Transcription Alternatively spliced transcript variants encodingPlays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5' and 3' splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5' splice site containing pre mRNA. Binds to purine rich RNA sequences, either the octamer, 5' RGAAGAAC 3' (r=A or G) or the decamers, AGGACAGAGC