UVRAG Polyclonal Antibody, 100ul Antibodies Tight junction strands serve as

Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets

An allelic variant encoding amino acid Lys at 915

The protein encoded by this gene interacts with the PBX1 homeodomain protein| inhibiting its transcriptional activation potential by preventing its binding to DNA

and is imprinted and expressed from the paternal allele

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UVRAG Polyclonal Antibody, 100ul Antibodies Tight junction strands serve asThis gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1 PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left right axis malformation and mutations in this gene have been associated with colon cancer.