Caspase-8 Polyclonal Antibody, 20ul[BT-AP07124] Plasmid Preparation The protein encoded by CLEC6A

The protein encoded by CLEC6A (C-type lectin domain family 6 member A) is a type II membrane receptor with an extracellular C-type lectin-like domain fold

This membrane-associated| cytoplasmic protein functions as a guanine nucleotide exchange factor and is involved in regulation of adherens junctions between cells

and the truncated form additionally interacts with CCR1 and CCR2

NF-kappa-B moves to the nucleus and activates transcription of specific genes

An important paralog of this gene is BARX2

Caspase-8 Polyclonal Antibody, 20ul[BT-AP07124] Plasmid Preparation The protein encoded by CLEC6AThis gene encodes a member of the cysteine aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large