FADD Polyclonal Antibody, 50ul[BT-AP03129] Cell Function Analysis APLP2 encodes amyloid precursor- like

APLP2 encodes amyloid precursor- like protein 2 (APLP2)

This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein

Belongs to the CREG family

This gene is often deleted or methylated and silenced in cancer cells

The encoded protein associates with the heat-shock protein Hsc70 and plays a role in clathrin-mediated endocytosis

FADD Polyclonal Antibody, 50ul[BT-AP03129] Cell Function Analysis APLP2 encodes amyloid precursor- likeProtein FADD encoded by FADD is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C terminal death domain, protein FADD can be recruited by TNFRSF6 Fas receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10 TRAIL receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of protein FADD with the receptors unmasks the N terminal