PERK Monoclonal Antibody, 100ul In vitro Assessment It is a disulfide-linked homotrimeric

It is a disulfide-linked homotrimeric glycoprotein that mediates cell-to-cell and cell-to-matrix interactions

Phosphorylation of the encoded protein targets it for destruction by the ubiquitin pathway

Alternatively spliced transcript variants encoding different isoforms have been found for TP53I3

It serves a variety of functions

A pseudogene has been identified on chromosome 3q29

PERK Monoclonal Antibody, 100ul In vitro Assessment It is a disulfide-linked homotrimericThe protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in