VRK1 Polyclonal Antibody, 100ul Insect Expression The proteins of this family

The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators

Binding of 53BP1 to the L3 loop of p53 and of 53BP2 to the L2 loop of p53 confirms that the loop is dependent on p53 conformation

Sequence variations in this gene may also be be associated with psychiatric disorders

suggesting an important role in p53/TP53 stress response such as DNA damage

KIR proteins are thought to play an important role in regulation of the immune response

VRK1 Polyclonal Antibody, 100ul Insect Expression The proteins of this familyThis gene encodes a member of the vaccinia related kinase (VRK) family of serine threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate