Human Ras-related Protein Rab-27A, RAB27A ELISA Kit , 96T Diagnostic Probes & Oligos Both BRCA1 and BRCA2 are

Both BRCA1 and BRCA2 are involved in maintenance of genome stability

The encoded protein can act as a homodimer or as a heterodimer with SPRED2 to regulate activation of the MAP kinase cascade

also known as neuralized-like protein 4

The protein is required for transcription by promoters targeted by RNA polymerase II

This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases

Human Ras-related Protein Rab-27A, RAB27A ELISA Kit , 96T Diagnostic Probes & Oligos Both BRCA1 and BRCA2 areSmall GTPase which cycles between active GTP bound and inactive GDP bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion (PubMed: 30771381). Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse.