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ANR11 Rabbit Polyclonal Antibody, 20ul Monoclonal Antibody Preparation In a non-canonical activation pathway|

SKU: 65013767193

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ANR11 Rabbit Polyclonal Antibody, 20ul Monoclonal Antibody Preparation In a non-canonical activation pathway|This locus encodes an ankryin repeat domain containing protein. The encoded protein inhibits ligand dependent activation of transcription. Mutations in this gene have been associated with KBG syndrome which is characterized by macrodontia distinctive craniofacial features short stature skeletal anomalies global developmental delay seizures and intellectual disability. Alternatively spliced transcript variants have been described. Related pseudogenes

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Description

In a non-canonical activation pathway| the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB| inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes

CD160 is expressed at the cell surface as a tightly disulfide-linked multimer

delta-type and kappa-type

Isoform 3 is the predominant isoform detected in the blood

prevention of aggregation

ANR11 Rabbit Polyclonal Antibody, 20ul Monoclonal Antibody Preparation In a non-canonical activation pathway|This locus encodes an ankryin repeat domain containing protein. The encoded protein inhibits ligand dependent activation of transcription. Mutations in this gene have been associated with KBG syndrome which is characterized by macrodontia distinctive craniofacial features short stature skeletal anomalies global developmental delay seizures and intellectual disability. Alternatively spliced transcript variants have been described. Related pseudogenes

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