MARE2 Polyclonal Antibody, 20ul Centrifuge Tube (Bottle) The enzyme is activated by

The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation

Additional splice variants have been described but sequences for the complete transcripts have not been determined

Loss of sequences from human chromosome 10q has been associated with the progression of human cancers

Promotes the exchange of GDP to GTP

Belongs to the phospholipase D family

MARE2 Polyclonal Antibody, 20ul Centrifuge Tube (Bottle) The enzyme is activated byThe protein encoded by this gene shares significant homology to the adenomatous polyposis coli (APC) protein binding EB1 gene family. This protein is a microtubule associated protein that is necessary for spindle symmetry during mitosis. It is thought to play a role in the tumorigenesis of colorectal cancers and the proliferative control of normal cells. Alternative splicing of this gene results in multiple transcript variants.