ASPP2 Polyclonal Antibody, 100ul Funnels The encoded protein is localized

The encoded protein is localized to the nucleus and may be involved in regulating the expression of interleukin 10

Mutations in TH have been associated with autosomal recessive Segawa syndrome

Mutations in this gene are associated with lung cancer

and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events

which is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB

ASPP2 Polyclonal Antibody, 100ul Funnels The encoded protein is localizedThis gene encodes a member of the ASPP (apoptosis stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein protein interactions. It is localized to the perinuclear region of the cytoplasm, and regulates apoptosis and cell growth through interactions with other regulatory molecules including members of the p53 family. Multiple transcript variants encoding different