Topo IIIBeta-1 Polyclonal Antibody, 100ul Immunoassays GO annotations related to this

GO annotations related to this gene include sequence-specific DNA binding and p53 binding

The encoded protein is required for the ubiquitination and subsequent degradation of the anti-apoptotic protein Mcl1 (myeloid cell leukemia sequence 1 (BCL2-related))

Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS)

This gene encodes a member of the tachykinin family of secreted neuropeptides

which often serves as a protein-protein interaction domain

Topo IIIBeta-1 Polyclonal Antibody, 100ul Immunoassays GO annotations related to thisTOP3B encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus relaxing the supercoils and altering the topology of DNA. The enzyme interacts with DNA helicase SGS1 and plays a role in DNA recombination, cellular aging and maintenance of genome