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Rb Polyclonal Antibody, 50ul[BT-AP07685] Peptide Library This gene is one of

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Rb Polyclonal Antibody, 50ul[BT-AP07685] Peptide Library This gene is one ofRB transcriptional corepressor 1 encoded by RB1 is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.

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Description

This gene is one of the contiguous genes at 7q11

This enzyme is an ADP-ribose pyrophosphatase that catalyzes the hydrolysis of ADP-ribose to AMP and ribose-5-P

It plays a neuroprotective role and functions as an E3-ubiquitin ligase in proteasome-mediated degradation of target proteins

This gene encodes a receptor for ephrin-B family members

is a type II membrane glycoprotein that exists as a disulfide-linked homodimer of two identical subunits

Rb Polyclonal Antibody, 50ul[BT-AP07685] Peptide Library This gene is one ofRB transcriptional corepressor 1 encoded by RB1 is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.

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