Phospho-Bcl-2 (T69) Polyclonal Antibody, 100ul DNA/RNA Isolation & Purification Leucine-rich repeat-containing protein 41 is

Leucine-rich repeat-containing protein 41 is a probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins

Two alternatively spliced transcript variants have been described

a subpopulation that does not interact with catenins

A similar but distinct gene (TAF9L) has been found on the X chromosome and a pseudogene has been identified on chromosome 19

The encoded cytosolic protein and mitochondrial glycerol-3-phosphate dehydrogenase also form a glycerol phosphate shuttle that facilitates the transfer of reducing equivalents from the cytosol to mitochondria

Phospho-Bcl-2 (T69) Polyclonal Antibody, 100ul DNA/RNA Isolation & Purification Leucine-rich repeat-containing protein 41 isBCL2 (BCL2, apoptosis regulator) encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Alternative splicing results in multiple transcript variants.