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GPVI Polyclonal Antibody, 50ul General Lab Use The paired immunoglobulin-like receptor genes

SKU: 46706112596

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GPVI Polyclonal Antibody, 50ul General Lab Use The paired immunoglobulin-like receptor genesThis gene encodes a platelet membrane glycoprotein of the immunoglobulin superfamily. The encoded protein is a receptor for collagen and plays a critical role in collagen induced platelet aggregation and thrombus formation. The encoded protein forms a complex with the Fc receptor gamma chain that initiates the platelet activation signaling cascade upon collagen binding. Mutations in this gene are a cause of platelet type bleeding disorder 11

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Description

The paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7

They all encode evolutionarily conserved glycosyltransferases that act in the Notch signaling pathway to define boundaries during embryonic development

The encoded protein (anaphase promoting complex subunit 5) is required for the proper ubiquitination function of APC/C and for the interaction of APC/C with transcription coactivators

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This gene encodes a member of the beta-microseminoprotein family

GPVI Polyclonal Antibody, 50ul General Lab Use The paired immunoglobulin-like receptor genesThis gene encodes a platelet membrane glycoprotein of the immunoglobulin superfamily. The encoded protein is a receptor for collagen and plays a critical role in collagen induced platelet aggregation and thrombus formation. The encoded protein forms a complex with the Fc receptor gamma chain that initiates the platelet activation signaling cascade upon collagen binding. Mutations in this gene are a cause of platelet type bleeding disorder 11

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