POLR3B Polyclonal Antibody, 20ul Mammalian Expression Histone deacetylation modulates chromatin structure

Histone deacetylation modulates chromatin structure

The encoded protein plays a role in multiple aspects of mRNA maturation and is associated with several multiprotein complexes including the apoB RNA editing-complex and survival of motor neurons (SMN) complex

This protein is also overexpressed in a large number of malignant neoplasms and precancerous dysplasias

which is functionally related to SWI/SNF complex in S

Defects in S1PR2 have been associated with congenital profound deafness

POLR3B Polyclonal Antibody, 20ul Mammalian Expression Histone deacetylation modulates chromatin structurePOLR3B (RNA polymerase III subunit B) encodes the second largest subunit of RNA polymerase III, the polymerase responsible for synthesizing transfer and small ribosomal RNAs in eukaryotes. The largest subunit and the encoded protein form the catalytic center of RNA polymerase III. Mutations in this gene are a cause of hypomyelinating leukodystrophy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for POLR3B.